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pentobarbital decreases levels of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers maximize fee of toremifene metabolism, reducing the steady-condition focus in serum.pentobarbital will decrease the extent or impact of dasatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use